BDBM373147 US9896452, Ex. A85::US9896452, Example 11::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

SMILES C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC5CN6)nn(C)c4c3F)c12

InChI Key InChIKey=SVCKMOGUOXOQCC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373147   

TargetGTPase NRas [G12D](Human)
University of Texas System

US Patent
LigandChemical structure of BindingDB Monomer ID 373147BDBM373147(4-(3-(2,5-diazabicyclo[2.2.2]octan-2-yl)-7- fluoro...)
Affinity DataKd:  73.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent