BDBM373168 US9896452, Example 28::rac-(2-(((5-chloropyrimidin-2-yl)amino)methyl)-6-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

SMILES C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c([C@H]5[C@@H]6CNC[C@@H]65)nn(C5C[C@@H]5C)c4c3F)c12

InChI Key InChIKey=IAZXUHGMBKWBCV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373168   

TargetGTPase NRas [G12D](Human)
University of Texas System

US Patent
LigandChemical structure of BindingDB Monomer ID 373168BDBM373168(US20260022118, Example 46)
Affinity DataKd:  60.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent