BDBM373357 ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A114

SMILES Cc1cc2c(F)c(Oc3ccnn4cc(C(=O)N5CC(C#N)C5)c(C)c34)ccc2[nH]1

InChI Key InChIKey=SXXWINNBQHFSOH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373357   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373357BDBM373357(1-{4-[(4-fluoro-2-methyl-1H- indol-5-yl)oxy]-5- me...)
Affinity DataEC50:  1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent