BDBM373476 (4,5-difluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A243

SMILES CC(=O)NC1CN(C(=O)c2cn3nccc(Oc4ccc5c(C(=O)NCC6CC6)c(C)oc5c4)c3c2C)C1

InChI Key InChIKey=GVXZUOBZCHXFNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373476   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373476BDBM373476(6-({6-[3- (acetylamino)azetidine-1- carbonyl]-5-me...)
Affinity DataEC50:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent