BDBM373477 ((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A244

SMILES COC1CN(C(=O)c2cn3nccc(Oc4ccc5c(C(=O)NC6CCC6)c(C)oc5c4)c3c2C)C1

InChI Key InChIKey=SBTWFFJFXDIIKU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373477   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373477BDBM373477(N-cyclobutyl-6-{[6-(3- methoxyazetidine-1-carbonyl...)
Affinity DataEC50:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent