BDBM373511 3-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidine-1-carbonyl)-4-(pyrimidin-2-yl)benzonitrile::US9896452, Ex. A323

SMILES Cc1oc2cc(Oc3ccnn4cc(C(=O)N5CC(O)C5)c(C)c34)ccc2c1C(=O)N[C@H]1CC[C@H]1F

InChI Key InChIKey=XQLMRBHDVDZUPQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373511   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373511BDBM373511(N-[(1S,2R or 1R,2S)-2- fluorocyclobutyl]-6-{[6-(3-...)
Affinity DataEC50:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent