BDBM375436 US10358436, Example A148::US9907800, Example A148

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)C(=O)N3CCN(C)CC3)c2c1

InChI Key InChIKey=KRDUFZIYLQNDNC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 375436   

TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

US Patent
LigandPNGBDBM375436(US9907800, Example A148 | US10358436, Example A148)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM375436(US9907800, Example A148 | US10358436, Example A148)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandPNGBDBM375436(US9907800, Example A148 | US10358436, Example A148)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375436(US9907800, Example A148 | US10358436, Example A148)
Affinity DataIC50: 550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375436(US9907800, Example A148 | US10358436, Example A148)
Affinity DataIC50: 550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent