BDBM375469 US9907800, Example A178

SMILES COc1ccc2c(c1)[C@]1(CC1c1ccc3c(/C=C/c4ccc(CCN5CCOCC5)cc4)n[nH]c3c1)C(=O)N2

InChI Key InChIKey=XAWWDXITYFPCFQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 375469   

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375469BDBM375469(US9907800, Example A178)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375469BDBM375469(US9907800, Example A178)
Affinity DataIC50: 100nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375469BDBM375469(US9907800, Example A178)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent