BDBM376169 (R)-N-(1-phenylethyl)-5H- chromeno[3,4-c]pyridine-8- carboxamide::US9914740, I-51

SMILES C[C@@H](NC(=O)c1ccc-2c(OCc3cnccc-23)c1)c1ccccc1

InChI Key InChIKey=JSBFPPNKJVBJKX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376169   

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376169(US9914740, I-51 | (R)-N-(1-phenylethyl)-5H- chrome...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376169(US9914740, I-51 | (R)-N-(1-phenylethyl)-5H- chrome...)
Affinity DataIC50: 3.23nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376169(US9914740, I-51 | (R)-N-(1-phenylethyl)-5H- chrome...)
Affinity DataIC50: 18nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed