BDBM376392 6-ethyl-N-(3-(ethylcarbamoyl)- 4-fluorobenzyl)-6H- isochromeno[3,4-c]pyridine- 8-carboxamide::US9914740, VIII-18::US9914740, XI-22::US9914740, XI-23

SMILES CCNC(=O)c1cc(CNC(=O)c2ccc-3c(c2)C(CC)Oc2cnccc-32)ccc1F

InChI Key InChIKey=OPMIJOFRYUMESR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 376392   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376392(US9914740, XI-22 | US9914740, XI-23 | 6-ethyl-N-(3...)
Affinity DataIC50: 2.95nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376392(US9914740, XI-22 | US9914740, XI-23 | 6-ethyl-N-(3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376392(US9914740, XI-22 | US9914740, XI-23 | 6-ethyl-N-(3...)
Affinity DataIC50: 5.16nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376392(US9914740, XI-22 | US9914740, XI-23 | 6-ethyl-N-(3...)
Affinity DataIC50: 7.34nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376392(US9914740, XI-22 | US9914740, XI-23 | 6-ethyl-N-(3...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed