BDBM376423 (R)-N-(1-(3-Methoxyphenyl)ethyl)-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-8-carboxamide::US9914740, X-3

SMILES COc1cccc(c1)[C@@H](C)NC(=O)c1ccc2c(c1)[nH]c(=O)c1cnccc21

InChI Key InChIKey=PDSLHUWAGNRMJH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376423   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376423(US9914740, X-3 | (R)-N-(1-(3-Methoxyphenyl)ethyl)-...)
Affinity DataIC50: 13.3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376423(US9914740, X-3 | (R)-N-(1-(3-Methoxyphenyl)ethyl)-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376423(US9914740, X-3 | (R)-N-(1-(3-Methoxyphenyl)ethyl)-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed