BDBM376455 2-amino-N-[(1R)-1-(3- methoxyphenyl)ethyl]- 6H-isochromeno [3,4-c] pyridine-8-carboxamide::US9914740, XI-30

SMILES COc1cccc(c1)[C@@H](C)NC(=O)c1ccc-2c(COc3cnc(N)cc-23)c1

InChI Key InChIKey=BEPHQLKTGFSXCX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376455   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376455(US9914740, XI-30 | 2-amino-N-[(1R)-1-(3- methoxyph...)
Affinity DataIC50: 15.9nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376455(US9914740, XI-30 | 2-amino-N-[(1R)-1-(3- methoxyph...)
Affinity DataIC50: 16nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376455(US9914740, XI-30 | 2-amino-N-[(1R)-1-(3- methoxyph...)
Affinity DataIC50: 171nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed