BDBM377100 3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimidin-1-yl)ethyl]-7- chloro-6-fluoro-2-methyl- 2,3-dihydro-1,4- benzoxazepin-4(5H)- yl]azetidine-1-sulfonamide::US10259818, Example 82::US9944646, Example 82

SMILES CC(c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CN(C1)S(N)(=O)=O)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=QKOVUJOJPYOKRE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377100   

LigandPNGBDBM377100(US9944646, Example 82 | US10259818, Example 82 | 3...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

LigandPNGBDBM377100(US9944646, Example 82 | US10259818, Example 82 | 3...)
Affinity DataIC50: 100nMAssay Description:[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent