BDBM380113 4-oxo-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-5-(propan-2- yl)-3H,4H-pyrrolo[2,1- f][1,2,4]triazine-6- carboxamide::US9926282, Example 108

SMILES CC(C)c1c(cn2nc[nH]c(=O)c12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12

InChI Key InChIKey=MGVBGLCUYUWDBS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380113   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380113(4-oxo-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phe...)
Affinity DataIC50: <100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380113(4-oxo-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phe...)
Affinity DataIC50:  550nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent