BDBM380648 6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-5-(3,7-dimethylbenzo[d]-isoxazol-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 34

SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3onc(C)c3c2)c(OC)n1

InChI Key InChIKey=OTZHGAAUXLOJFP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380648   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380648BDBM380648(US9890166, Example 34 | 6-(4-chlorophenyl)-2-(2,4-...)
Affinity DataIC50: 65.2nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380648BDBM380648(US9890166, Example 34 | 6-(4-chlorophenyl)-2-(2,4-...)
Affinity DataIC50: 76.5nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380648BDBM380648(US9890166, Example 34 | 6-(4-chlorophenyl)-2-(2,4-...)
Affinity DataIC50: 98.2nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380648BDBM380648(US9890166, Example 34 | 6-(4-chlorophenyl)-2-(2,4-...)
Affinity DataIC50: 1.67E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent