BDBM380706 6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-6-yl)-1-(oxetan-3-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 93

SMILES CN1N=NC2C=CC(N3C(=O)c4nc(C5=CCOCC5)n(C5COC5)c4C3c3ccc(Cl)cc3)=CC21

InChI Key InChIKey=OIAZLVBSFCYPRC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 380706   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380706BDBM380706(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Affinity DataIC50: 21.5nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380706BDBM380706(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Affinity DataIC50: 34nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380706BDBM380706(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Affinity DataIC50: 2.70E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent