BDBM380806 8-(3-Methyl-1H-indazol-5-yl)-3,4- dihydro-1H-pyrano[4,3-c]pyridin-4- ol, Enantiomer I::US9890171, 10::US9890171, 12

SMILES Cc1n[nH]c2ccc(cc12)-c1cncc2C(O)COCc12

InChI Key InChIKey=QOHCTXDXLKKKMF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380806   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380806(US9890171, 12 | 8-(3-Methyl-1H-indazol-5-yl)-3,4- ...)
Affinity DataIC50: 21nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380806(US9890171, 12 | 8-(3-Methyl-1H-indazol-5-yl)-3,4- ...)
Affinity DataIC50: 115nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent