BDBM380812 8-(1-methylindazol-6-yl)spiro[1,4- dihydropyrano[4,3-c]pyridine-3,1''- cyclopropane]-4-ol, Enantiomer I::US9890171, 16::US9890171, 17

SMILES Cn1ncc2ccc(cc12)-c1cncc2C(O)C3(CC3)OCc12

InChI Key InChIKey=BLUXNCBQIAYMKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380812   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380812(8-(1-methylindazol-6-yl)spiro[1,4- dihydropyrano[4...)
Affinity DataIC50: 8nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380812(8-(1-methylindazol-6-yl)spiro[1,4- dihydropyrano[4...)
Affinity DataIC50: 12.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent