BDBM380826 8-Isoquinolin-6-yl-3,4-dihydro-1H- pyrano[4,3-c]pyridin-4-ol, Enantiomer I::US9890171, 30::US9890171, 45

SMILES OC1COCc2c1cncc2-c1ccc2cnccc2c1

InChI Key InChIKey=KZSYLXXMLKMQJM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380826   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380826(US9890171, 45 | 8-Isoquinolin-6-yl-3,4-dihydro-1H-...)
Affinity DataIC50: 5.80nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380826(US9890171, 45 | 8-Isoquinolin-6-yl-3,4-dihydro-1H-...)
Affinity DataIC50: 54nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent