BDBM380872 N-[8-(1-Methyl-1H-indazol-6-yl)-3,4- dihydro-1H-pyrano[4,3-c]pyridin-4- yl]-propionamide, Enantiomer II::US9890171, 155::US9890171, 76

SMILES CCC(=O)NC1COCc2c1cncc2-c1ccc2cnn(C)c2c1

InChI Key InChIKey=SNFZFKOKWYRBRL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380872   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380872(N-[8-(1-Methyl-1H-indazol-6-yl)-3,4- dihydro-1H-py...)
Affinity DataIC50: 17.9nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380872(N-[8-(1-Methyl-1H-indazol-6-yl)-3,4- dihydro-1H-py...)
Affinity DataIC50: 3.80E+3nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent