BDBM380921 6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-8-yl)-chromen- 2-one, Enantiomer I::US9890171, 125::US9890171, 126

SMILES OC1COCc2c1cncc2-c1ccc2oc(=O)ccc2c1

InChI Key InChIKey=OQVLRENQTYZUSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380921   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380921(6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 14nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380921(6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 22.8nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent