BDBM381665 US10272079, Compound 22

SMILES CN1C[C@@H](c2cccc(c2)S(=O)(=O)NCCOCCOCCOCCN)c2cc(Cl)cc(Cl)c2C1

InChI Key InChIKey=INYHTNOHKPVFNR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 381665   

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 381665BDBM381665(US10272079, Compound 22)
Affinity DataIC50: 501nMAssay Description:Inhibition of human NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibito...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 381665BDBM381665(US10272079, Compound 22)
Affinity DataIC50: 794nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed