BDBM381954 US10273214, Example 1418

SMILES C#C[C@H]1C[C@@H]1c1nnc(NC(=O)c2cnc(-n3cc(C)ccc3=O)cc2-c2cc(C(F)F)ncc2OC)s1

InChI Key InChIKey=SZWFRYMHGAWGCD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 381954   

TargetDNA polymerase theta [1-894](Homo sapiens (Human))
Repare Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 381954BDBM381954(US20260022114, Compound 546)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent