BDBM381987 2-{1-[2-(1H-pyrazol-1-yl)ethyl]- 1H-imidazol-4-yl}pyridine-4- carboxylic acid::US10273222, Example 46

SMILES OC(=O)c1ccnc(c1)-c1cn(CCn2cccn2)cn1

InChI Key InChIKey=FJDQJUPBHKHILS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 381987   

TargetLysine-specific demethylase 5A(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 381987BDBM381987(2-{1-[2-(1H-pyrazol-1-yl)ethyl]- 1H-imidazol-4-yl}...)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 2B(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 381987BDBM381987(2-{1-[2-(1H-pyrazol-1-yl)ethyl]- 1H-imidazol-4-yl}...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 381987BDBM381987(2-{1-[2-(1H-pyrazol-1-yl)ethyl]- 1H-imidazol-4-yl}...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 381987BDBM381987(2-{1-[2-(1H-pyrazol-1-yl)ethyl]- 1H-imidazol-4-yl}...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent