BDBM382016 2-[1-[2-(1,3-dihydroisoindol-2- yl)ethyl]imidazol-4-yl]pyridine-4- carboxylic acid::US10273222, Example 76

SMILES OC(=O)c1ccnc(c1)-c1cn(CCN2Cc3ccccc3C2)cn1

InChI Key InChIKey=HCQJMYQADHVXJR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 382016   

TargetLysine-specific demethylase 4C(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 382016BDBM382016(2-[1-[2-(1,3-dihydroisoindol-2- yl)ethyl]imidazol-...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 382016BDBM382016(2-[1-[2-(1,3-dihydroisoindol-2- yl)ethyl]imidazol-...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5A(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 382016BDBM382016(2-[1-[2-(1,3-dihydroisoindol-2- yl)ethyl]imidazol-...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 2B(Human)
Celgene Quantscel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 382016BDBM382016(2-[1-[2-(1,3-dihydroisoindol-2- yl)ethyl]imidazol-...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent