BDBM382112 (R)-6-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-5-(isopropylamino)-N-methylpyrazine-2-carboxamide::US10000468, Example 21::US10273225, Example 21

SMILES COc1cnc(C(F)F)cc1-c1cc(-n2ccc(C)cc2=O)ncc1C(=O)Nc1nnc([C@H]2C[C@@H]2c2ccc(C#N)cc2)s1

InChI Key InChIKey=DJYGHIQUHQRKOQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 382112   

TargetDNA polymerase theta [1-894](Homo sapiens (Human))
Repare Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 382112BDBM382112(US20260022114, Compound 563)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent