BDBM38237 CHEMBL491687::US10201527, Compound 33::US10736881, Compound 33::US8551988, 33

SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccc3)c(CCc3ccccc3)nc2c1

InChI Key InChIKey=QYNCCBBQZDWNDI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 38237   

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM38237(CHEMBL491687 | US8551988, 33 | US10201527, Compoun...)
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM38237(CHEMBL491687 | US8551988, 33 | US10201527, Compoun...)
Affinity DataIC50: 449nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM38237(CHEMBL491687 | US8551988, 33 | US10201527, Compoun...)
Affinity DataIC50: 449nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM38237(CHEMBL491687 | US8551988, 33 | US10201527, Compoun...)
Affinity DataIC50: 449nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM38237(CHEMBL491687 | US8551988, 33 | US10201527, Compoun...)
Affinity DataIC50: 1.45E+3nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM38237(CHEMBL491687 | US8551988, 33 | US10201527, Compoun...)
Affinity DataIC50: 1.45E+3nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM38237(CHEMBL491687 | US8551988, 33 | US10201527, Compoun...)
Affinity DataIC50: 1.45E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent