BDBM383261 4-(3-benzyl-3,4-dihydro-5- oxa-1,2,2a1- triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyridin-2-amine::US10278975, Compound I-38 R::US11376260, Example I-38R

SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OC[C@H](Cc3ccccc3)c3nnc(c1)n23

InChI Key InChIKey=VJZKAABDYWPRQY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 383261   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM383261(4-(3-benzyl-3,4-dihydro-5- oxa-1,2,2a1- triazaacen...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 6(Human)
Genentech

US Patent
LigandPNGBDBM383261(4-(3-benzyl-3,4-dihydro-5- oxa-1,2,2a1- triazaacen...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
US Patent