BDBM383286 N-(1-methyl-1H-pyrazol-5- yl)-4-(3-(2-methylbutyl)-3,4- dihydro-5-oxa-1,2,2a1- triazaacenaphthalen-7- yl)pyrimidin-2-amine::US10278975, Compound I-52 R::US11376260, Example I-52R

SMILES CCC(C)C[C@H]1COc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=MOCDOWIFFPUTEE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 383286   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM383286(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-(2-methylbutyl)...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 6(Human)
Genentech

US Patent
LigandPNGBDBM383286(N-(1-methyl-1H-pyrazol-5- yl)-4-(3-(2-methylbutyl)...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
US Patent