BDBM384357 US9932327, Compound Flavopiridol
SMILES C[N@]1CC[C@@H]([C@@H](C1)O)c2c(cc(c3c2OC(=CC3=O)c4ccccc4Cl)O)O
InChI Key InChIKey=BIIVYFLTOXDAOV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 384357
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin) using ULight MBP peptide as substrate in presence of ATP incubated for 1 hr by FRET based LANCE Ultra K...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK1/Cyclin B1 (unknown origin) using ULight MBP peptide as substrate in presence of ATP incubated for 1 hr by FRET based LANCE Ultra K...More data for this Ligand-Target Pair
Affinity DataKd: <5nMAssay Description:Displacement of kinase tracer 236 from CDK9/Cyclin T1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kinase ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human CDK9/cyclin T1More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
The Council of Scientific & Industrial Research
US Patent
The Council of Scientific & Industrial Research
US Patent
Affinity DataIC50: 20nMAssay Description:CDK-9/Cyclin T1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 1 mg/ml BSA, 0.1% mercaptoethanol) was assayed against a substrate peptide (YSPTS...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 38nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) using ULight MBP peptide as substrate in presence of ATP incubated for 1 hr by FRET based LANCE Ultra K...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human N-terminal GST-fused CDK4 (S4 to E303 residues)/cyclin D1 expressed in Sf9 insect cells using C-terminal Rb fragment ...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Binding affinity to CDK1/Cyclin B (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
Affinity DataEC50: 55nMAssay Description:Inhibition of CDK4/CDK6 in human COLO 205 cells assessed as reduction in Rb phosphorylation at S780 residue measured after 24 hrs by laser-scanning f...More data for this Ligand-Target Pair
Affinity DataKd: 96nMAssay Description:Displacement of kinase tracer 236 from CDK7/Cyclin H/MAT1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kin...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Inhibition of CDK7/Cyclin H/MAT1 (unknown origin) using ULight MBP peptide as substrate in presence of ATP incubated for 1 hr by FRET based LANCE Ult...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Council of Scientific & Industrial Research
US Patent
The Council of Scientific & Industrial Research
US Patent
Affinity DataIC50: 170nMAssay Description:CDK-2/cyclin A (5-20 mU diluted in 50 mM Hepes pH 7.5, 1 mM DTT, 0.02% Brij35, 100 mM NaCl) was assayed against Histone H1 in a final volume of 25.5 ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 177nMAssay Description:Inhibition of CDK9 in human U2OS cells assessed as reduction in CTD phosphorylation at Ser2 residue measured after 16 hrs by propidium iodide stainin...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 305nMAssay Description:Inhibition of CDK6/Cyclin D3 (unknown origin) using ULight MBP peptide as substrate in presence of ATP incubated for 1 hr by FRET based LANCE Ultra K...More data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of human PKC epsilonMore data for this Ligand-Target Pair
Affinity DataIC50: 890nMAssay Description:Inhibition of human PKC deltaMore data for this Ligand-Target Pair