BDBM384568 4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)piperidin- 1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile::US9932350, 3-2

SMILES FC(F)(F)C1CCCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N

InChI Key InChIKey=ALTVKDPSXAFXEM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384568   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 384568BDBM384568(US9932350, 3-2 | 4-({cis or trans-4-[(3R or S)-3- ...)
Affinity DataIC50: 33nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent