BDBM387106 (3aR, 7aR)-6-{[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}-1-[4- (trifluoromethyl)pyridin-2-yl]octahydro-1H- pyrrolo[2,3-c]pyridine::US9938276, A20

SMILES Clc1c(ccnc1N1CC[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1)C#N

InChI Key InChIKey=VBANNTZAIIOPRG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387106   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM387106((3aR, 7aR)-6-{[2-(2H-1,2,3-triazol-2- yl)phenyl]ca...)
Affinity DataIC50: 66.5nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM387106((3aR, 7aR)-6-{[2-(2H-1,2,3-triazol-2- yl)phenyl]ca...)
Affinity DataIC50: 3.96E+3nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent