BDBM387237 US9938274, 3

SMILES COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2cc1OCC(C)(C)O

InChI Key InChIKey=IGPDFRGHANCKMA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387237   

TargetHepatocyte growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM387237(US9938274, 3)
Affinity DataIC50: 20nMAssay Description:Inhibition of MET (unknown origin) using biotin as substrate preincubated for 5 mins followed by substrate addition and measured after 30 to 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM387237(US9938274, 3)
Affinity DataIC50: 20.1nMAssay Description:A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Nanjing Natinefy Pharmatech

US Patent
LigandPNGBDBM387237(US9938274, 3)
Affinity DataIC50: 48.9nMAssay Description:A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent