BDBM387259 US9938274, Comparative Compound A

SMILES COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1

InChI Key InChIKey=TYOVUEVLYPWSPH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387259   

TargetHepatocyte growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM387259(US9938274, Comparative Compound A)
Affinity DataIC50: 41nMAssay Description:Inhibition of MET (unknown origin) using biotin as substrate preincubated for 5 mins followed by substrate addition and measured after 30 to 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM387259(US9938274, Comparative Compound A)
Affinity DataIC50: 68.3nMAssay Description:A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Nanjing Natinefy Pharmatech

US Patent
LigandPNGBDBM387259(US9938274, Comparative Compound A)
Affinity DataIC50: 125nMAssay Description:A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent