BDBM387928 (S)-N-(1-(3-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(methylamino)-2-oxo-1,6-naphthyridin-1(2H)-yl)propyl)pyrrolidin-3-yl)acrylamide::US10294223, Cpd No. 154::US11078199, Cpd 154

SMILES CNc1cc2n(CCCN3CC[C@@H](C3)NC(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl

InChI Key InChIKey=CLOKMQGAUMQXSE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387928   

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 387928BDBM387928((S)-N-(1-(3-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 22nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 387928BDBM387928((S)-N-(1-(3-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 22nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent