BDBM388381 US10294246, Compound No. 78

SMILES COc1ccc(OC)c(CC(=O)N[C@@H](Cc2coc3c(C)cccc23)B(O)O)c1

InChI Key InChIKey=YOLPKPRMYXWSGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 388381   

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM388381(US10294246, Compound No. 78)
Affinity DataIC50: 50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM388381(US10294246, Compound No. 78)
Affinity DataIC50: 2.75E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent