BDBM388418 US10294246, Compound No. 115::US10294246, Compound No. 122

SMILES COc1ccc(CC(=O)N[C@@H](C[C@H]2COc3ccccc23)B(O)O)cc1

InChI Key InChIKey=CIBBBLQQDLHWDY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 388418   

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM388418(US10294246, Compound No. 122 | US10294246, Compoun...)
Affinity DataIC50: 50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM388418(US10294246, Compound No. 122 | US10294246, Compoun...)
Affinity DataIC50: 275nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM388418(US10294246, Compound No. 122 | US10294246, Compoun...)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM388418(US10294246, Compound No. 122 | US10294246, Compoun...)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent