BDBM388431 US10294246, Compound No. 128

SMILES Cc1ccc(C)c2c(C[C@H](NC(=O)Cc3ccccc3)B(O)O)coc12

InChI Key InChIKey=MOCVIBSOLKDBBB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 388431   

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM388431(US10294246, Compound No. 128)
Affinity DataIC50: 50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM388431(US10294246, Compound No. 128)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent