BDBM388505 US9944618, Compound ID No. 134::US9944618, Compound ID No. 39

SMILES CNCC(Cc1ccccc1C)c1ccc2ccccc2c1

InChI Key InChIKey=GIXNEGGWWYHJGX-UHFFFAOYSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 388505   

TargetSodium-dependent noradrenaline transporter(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataKi:  3.10nMAssay Description:NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataKi:  6nMAssay Description:NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataKi:  7.80nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataKi:  12.6nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataKi:  34.3nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataKi:  56.8nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataIC50: 170nMAssay Description:Cytochrome P450 3A4 and 2D6:Recombinant enzymes, 3A4 and 2D6, generated using the ABL yeast expression system were used. For CYP3A4, the enzyme amoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataIC50: 220nMAssay Description:Cytochrome P450 3A4 and 2D6:Recombinant enzymes, 3A4 and 2D6, generated using the ABL yeast expression system were used. For CYP3A4, the enzyme amoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataIC50: 6.20E+3nMAssay Description:HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataIC50: 8.20E+3nMAssay Description:HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataIC50: 8.40E+3nMAssay Description:Cytochrome P450 3A4 and 2D6:Recombinant enzymes, 3A4 and 2D6, generated using the ABL yeast expression system were used. For CYP3A4, the enzyme amoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Mayo Foundation

US Patent
LigandPNGBDBM388505(US9944618, Compound ID No. 134 | US9944618, Compou...)
Affinity DataIC50: 9.90E+3nMAssay Description:Cytochrome P450 3A4 and 2D6:Recombinant enzymes, 3A4 and 2D6, generated using the ABL yeast expression system were used. For CYP3A4, the enzyme amoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent