BDBM389728 1-{(R)-4-[2-(2-Cyclopropyl-pyrimidin-5-yl)-5-trifluoromethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl]-2-methyl-piperazin-1-yl}-2-pyrazolo[3,4-b]pyridin-1-yl-ethanone::US9951063, 47

SMILES C[C@@H]1CN(CCN1C(=O)Cn1ncc2cccnc12)c1ccc(c2CCN(Cc12)c1cnc(nc1)C1CC1)C(F)(F)F

InChI Key InChIKey=PVVHGPJRFSLCDE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 389728   

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM389728(US9951063, 47 | 1-{(R)-4-[2-(2-Cyclopropyl-pyrimid...)
Affinity DataIC50: 7.27nMAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
US Patent