BDBM393015 2-butoxy-7-(4-(pyrrolidine-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-4-amine::US9962388, Compound Example 21

SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCC4)cc3)c2n1

InChI Key InChIKey=VMDGIQUJSYPMLF-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 393015   

TargetToll-like receptor 7(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM393015(US9962388, Compound Example 21 | 2-butoxy-7-(4-(py...)
Affinity DataEC50:  5.5nMAssay Description:Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM393015(US9962388, Compound Example 21 | 2-butoxy-7-(4-(py...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM393015(US9962388, Compound Example 21 | 2-butoxy-7-(4-(py...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed