BDBM393391 3-((4'-Cyano-5-phenoxy-[1,1'-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile::US9963444, Example 92

SMILES N#CN1CC(C1)OCc1ccc(Oc2ccccc2)cc1-c1ccc(cc1)C#N

InChI Key InChIKey=IGZLDQATHGARHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393391   

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393391(US9963444, Example 92 | 3-((4'-Cyano-5-phenoxy-[1,...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393391(US9963444, Example 92 | 3-((4'-Cyano-5-phenoxy-[1,...)
Affinity DataIC50: 55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent