BDBM393429 N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-(2,2- difluoroethyl)-1H-pyrazol-4-yl)- 2-(2,6-difluorophenyl)thiazole- 4-carboxamide::US9963446, Example 115

SMILES N[C@@H]1CC[C@H](OC[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1CC(F)F

InChI Key InChIKey=YZTUBLRWERYLLY-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393429   

TargetSerine/threonine-protein kinase pim-1(Human)
Genentech

US Patent
LigandPNGBDBM393429(US9963446, Example 115 | N-(5-((2S,5R,6S)-5-amino-...)
Affinity DataKi:  0.0470nMAssay Description:Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent