BDBM393436 N-[5-[(2S,5R,6S,7S)-5-amino-6- fluoro-7-methyl-oxepan-2-yl]-1- methyl-pyrazol-4-yl]-2-(2,6- difluorophenyl)thiazole-4- carboxamide::US9963446, Example 124

SMILES C[C@@H]1O[C@@H](CC[C@@H](N)[C@@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C

InChI Key InChIKey=HKRXJKSQNXPSLH-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393436   

TargetSerine/threonine-protein kinase pim-1(Human)
Genentech

US Patent
LigandPNGBDBM393436(US9963446, Example 124 | N-[5-[(2S,5R,6S,7S)-5-ami...)
Affinity DataKi:  0.0510nMAssay Description:Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent