BDBM393526 US12378251, Compound MLN4924::US9963456, Example Comp.

SMILES c1ccc2c(c1)CC[C@@H]2Nc3c4ccn(c4ncn3)[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N

InChI Key InChIKey=MPUQHZXIXSTTDU-UHFFFAOYSA-N

Data  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393526   

TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM393526(US9963456, Example Comp. | US12378251, Compound ML...)
Affinity DataIC50: 12nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

LigandPNGBDBM393526(US9963456, Example Comp. | US12378251, Compound ML...)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)