BDBM393944 5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}quinazolin-6- yl)pyridine-3-carboxylic acid::US9969749, Example 1-37

SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(c1)C(O)=O

InChI Key InChIKey=QTAHQMOAPADEBZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393944   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 393944BDBM393944(US9969749, Example 1-37 | 5-(4-{[trans-4- (dimethy...)
Affinity DataIC50: 504nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent