BDBM394404 N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-(morpholine-4-carbonyl)benzamide::US10307413, Compound 46::US10391089, Compound 46::US10980794, Cmpd No 46

SMILES OC(CNC(=O)c1cccc(c1)C(=O)N1CCOCC1)CN1CCc2ccccc2C1

InChI Key InChIKey=SGQMNJKLEADSRY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394404   

LigandChemical structure of BindingDB Monomer ID 394404BDBM394404(US10307413, Compound 46 | N-(3-(3,4-dihydroisoquin...)
Affinity DataIC50: 5.50E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 394404BDBM394404(US10307413, Compound 46 | N-(3-(3,4-dihydroisoquin...)
Affinity DataIC50: 5.50E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 394404BDBM394404(US10307413, Compound 46 | N-(3-(3,4-dihydroisoquin...)
Affinity DataIC50: 5.50E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent