BDBM394693 US10307413, Compound 336::US10307413, Compound 367::US11591326, Compound C2

SMILES O[C@H](CNC(=O)c1cc(NC2COC2)ncn1)CN1CCc2ccccc2C1

InChI Key InChIKey=ZKXZLIFRWWKZRY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394693   

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 394693BDBM394693(US10307413, Compound 336 | US10307413, Compound 36...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 394693BDBM394693(US10307413, Compound 336 | US10307413, Compound 36...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Pharmablock Sciences (Nanjing)

US Patent
LigandChemical structure of BindingDB Monomer ID 394693BDBM394693(US10307413, Compound 336 | US10307413, Compound 36...)
Affinity DataIC50: 794nMAssay Description:General Procedure for PRMT5/MEP50 AlphaLISA Enzyme Inhibitory Assays: Assays were performed in the buffer consisting of 50 mM Tris, pH 8.5, 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent