BDBM395282 N-{4-[[(4aR,5aR) or (4aS,5aS)]-3-Anilino-5a-methyl-4-oxo-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indol-2-yl]pyridin-2-yl}-2,6-difluorobenzamide::US10308629, Example 46::US10308629, Example 47

SMILES C[C@@]12Cc3[nH]c(-c4ccnc(NC(=O)c5c(F)cccc5F)c4)c(Nc4ccccc4)c3C(=O)[C@@H]1C2

InChI Key InChIKey=ODQJAVJRIJXVOY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395282   

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 395282BDBM395282(US10308629, Example 46 | N-{4-[[(4aR,5aR) or (4aS,...)
Affinity DataIC50: 4nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 395282BDBM395282(US10308629, Example 46 | N-{4-[[(4aR,5aR) or (4aS,...)
Affinity DataIC50: 7nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent