BDBM395557 (1R,3S)-3-((7-cyano-2-(3'-(3- (((R)-3-hydroxypyrrolidin-1- yl)methyl)-1,7-naphthyridin-8- ylamino)-2,2'-dimethyl biphenyl-3-yl)benzo[d]oxazol- 5-yl) methylamino)cyclopentane- carboxylic acid::US10308644, Example 169::US10800768, Example 169::US11339149, Example 169

SMILES Cc1c(Nc2nccc3cc(CN4CC[C@@H](O)C4)cnc23)cccc1-c1cccc(-c2nc3cc(CN[C@H]4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C

InChI Key InChIKey=MYSZFVAEIIPOKQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 395557   

LigandPNGBDBM395557(US10308644, Example 169 | (1R,3S)-3-((7-cyano-2-(3...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM395557(US10308644, Example 169 | (1R,3S)-3-((7-cyano-2-(3...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM395557(US10308644, Example 169 | (1R,3S)-3-((7-cyano-2-(3...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 uL. Inhibitors were first serially diluted in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM395557(US10308644, Example 169 | (1R,3S)-3-((7-cyano-2-(3...)
Affinity DataIC50: 3.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent